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Översiktsartikel om GFR-skattning - Svensk Förening för

The reliability of a determination of the total [51Cr]EDTA plasma clearance (E) (and with it the glomerular filtration rate), by a simplified single injection method (injected dose: 4.5 muCi per kg b.w.) using capillary blood samples (0.2 ml), was investigated in twenty children. From a large database of 51Cr-ethylenediaminetetraacetic acid (51Cr-EDTA) renal clearance determinations using the two blood sample method, 598 patients, aged 1 week to 90 years, were selected. The results of the 51Cr-EDTA slope intercept clearance of the two blood sample method were used as reference. that the 51Cr-EDTA clearance corresponds very closely with the inulin clearance when estimated by the standard infusion technique, quoting r values of 0.995 and 0.992, respectively. The renal handling of 51Cr-EDTA and inulin would therefore appear to be identical. Since "Cr-EDTA is not bound by plasma proteins and is Routine methods and their reliability for assessment of glomerular filtration rate in adults, with special reference to total [51Cr]EDTA plasma clearance Dan Med Bull . 1978 Oct;25(5):181-202.

Total plasma clearance of 51Cr‐EDTA, Cl, is widely used as a measure of GFR. Commonly, only the final part of the plasma concentration curve is measured, and a one‐pool clearance (slope‐intercept clearance), Cl1, is computed. Empirically determined second‐order polynomials of the general form Cl = b⋅Cl1+c⋅Cl12 are usually used to estimate Cl from a measured Cl1. The precision of two different clearance methods as used for routine assessment of the glomerular filtration rate (GFR) was investigated in thirty-one children aged 0.6–14 years: total [51 Cr]EDTA plasma clearance (E) determined by a simplified single injection method; and 24 h endogenous creatinine clearance (C).Determination of C twice only succeeded in twenty children because of problems 2009-01-01 1997-10-01 extraction ratio of 51Cr-EDTA are based on studies in our laboratory of 14 kidneys which had a normal clearance rate of 51Cr-EDTA, normal renograms, and a normal extraction ratio of PAH (Table 2). Results The HbA1 values are given in Table I. Mean SD for the group was … GFR measurement with iohexol and 51Cr-EDTA. A comparison of the two favoured GFR markers in Europe From a large database of 51Cr-ethylenediaminetetraacetic acid (51Cr-EDTA) renal clearance determinations using the two blood sample method, 598 patients, aged 1 week to 90 years, were selected. The results of the 51Cr-EDTA slope intercept clearance of the two blood sample method were used as reference.

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It was demonstrated that the two methods were closely related. that the 51Cr-EDTA clearance corresponds very closely with the inulin clearance when estimated by the standard infusion technique, quoting r values of 0.995 and 0.992, respectively. The renal handling of 51Cr-EDTA and inulin would therefore appear to be identical. Since "Cr-EDTA is not bound by plasma proteins and is Two groups of patients with 51Cr-EDTA clearance (Cl) between 16 and 172 ml/min were studied.

Glomerulär filtration - Läkartidningen

We propose that current methods for analysing the raw 51Cr EDTA measurements over-simplifies the disposition of 51Cr EDTA and therefore could produce biased GFR estimates. The reliability of a determination of the total [51Cr]EDTA plasma clearance (E) (and with it the glomerular filtration rate), by a simplified single injection method (injected dose: 4.5 muCi per kg b.w.) using capillary blood samples (0.2 ml), was investigated in twenty children. The calculation of 51Cr-EDTA clearance by method I (ClI) was based on a transformation of the biexponential time-activity curve into a monoexponential with identical area below the time-activity curve.

Relative to the pharmacokinetic model, 24h urine data provided unbiased GFR predictions. The slope-intercept method for isotopic GFR produced positively biased estimates (MPE 15.5 mL/min/1.73m 2 [95% CI 8.9, 22.2]). In 74 adult patients suffering from various renal diseases, the total [51Cr]EDTA plasma clearance (Cl) was compared to the [51Cr]EDTA clearance obtained on assuming a one-pool system (Cl1). The difference between the two methods was independent of the level of renal function. Similar results were found for one-sample GFR. No clinically relevant differences were found between the plasma clearance of 99m Tc-DTPA and that of 51 Cr-EDTA.
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The results of the 51Cr-EDTA slope intercept clearance of the two blood sample method were used as reference.

The single-sample method for GFR >40 ml/min can be used with a high accuracy. The precision and accuracy of X-ray fluorescence analysis of low concentrations of iohexol were less than those of HPLC.
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Skattning av njurfunktion, Methods to Estimate and - SBU

his method was further developed in Denmark using 51Cr-EDTA and as iohexol, inulin, 51Cr EDTA or 1125 iothalamate, or creatinine clearance of or to use one highly effective contraceptive method plus one barrier method. myelomeningocele: time for a decisionmaking process. Pediatrics. 1985 de individer som med.